#  Lynette Cegelski 

 



####  calendar\_today Date and Time 

 **April 9, 2018** 

 04:15PM - 05:15PM EDT 

####  pin\_drop Location 

 **Pfizer Lecture Hall**  



 

 



 

 Professor Lynette Cegelski, Stanford University. "New views of bacterial cell walls and biofilms." Woodward CCB Departmental Colloquium.

 Abstract: The bacterial cell wall is essential to cell survival and is a major target of antibiotics. Beyond the cell surface, bacteria assemble macromolecular architectures during biofilm formation. Biofilms are implicated in serious infectious diseases and have emerged as a target for anti-infectives. Our research program is inspired by the challenge and importance of elucidating chemical structure and function in these complex biological systems and we strive to transform our discoveries into new therapeutic strategies. We have introduced new approaches using whole-cell and cell-wall solid-state NMR, integrated with biochemical analysis and rheology measurements, to reveal how the biological functions of cell walls and biofilms depend on their chemical composition and architecture. We are probing the modes of action of newly discovered antimicrobials and anti-virulence compounds, including a number of promising compounds we have identified in our laboratory. I will report on our recent discoveries including: (i) the determination of cell-wall compositional changes due to antibiotics in the context of intact unperturbed cells; (ii) the composition and function of the amyloid-associated biofilm matrix for uropathogenic *E. coli*, including the biosynthetic production of a chemically modified cellulose; and (iii) small molecules that enhance our understanding of the composition and assembly of cell walls and biofilms.



 

 



 

 See also:- [ Woodward CCB Departmental Colloquium ](/seminars/woodward-ccb-departmental-colloquium)
 
 

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