#  Professor Amie Boal (Penn State) 

 



####  calendar\_today Date and Time 

 **April 9, 2025** 

 04:30PM - 05:45PM EDT 

####  pin\_drop Location 

 **Pfizer Lecture Hall**  



 

 



 

 Title: " The periodic table of ribonucleotide reductases "

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Abstract: All organisms depend on the action of a ribonucleotide reductase (RNR) to provide the substrates for DNA replication and repair. This central function offers potential for the development of new RNR inhibitors that could serve as potent antibiotics. All class I RNRs share a common nucleotide reduction mechanism, initiated in the catalytic (alpha) subunit by a cysteine thiyl radical that abstracts an H-atom from the substrate. Class I RNRs use diverse inorganic chemistry in a separate beta subunit to generate the thiyl radical transiently on each turnover. My research group seeks to identify diversity in class I RNR metallocofactor compositions, structures, and assembly mechanisms, with the eventual goal of targeted inhibition of these pathways in bacterial pathogens. We focus on discovery and characterization of new enzyme subclasses with the goal of gaining more detailed understanding of both cofactor assembly mechanisms and the roles of subclass-specific structural features.

Biography: Amie K. Boal received a Ph.D. in Chemistry in 2008 from the California Institute of Technology with Jacqueline K. Barton. She was a postdoctoral scholar in the Molecular Biosciences Department at Northwestern University from 2009-2013 with Amy C. Rosenzweig, funded by the NIH via a Ruth L. Kirschstein National Research Service Award and a Pathway to Independence Award. In 2013, she joined the faculty at Penn State in the Departments of Chemistry and of Biochemistry and Molecular Biology. Her independent research program focuses on understanding the structural basis for mechanism and function in diverse families of metalloenzymes. The Boal research group has been supported by the National Institutes of Health, the National Science Foundation, the Department of Energy, the Searle Scholars Program, the Camille Dreyfus Teacher-Scholar Program, and the Nicholas and Gelsa Pelick Family Chair in Science.



 

 



 

 See also:- [ Harvard/MIT Inorganic Chemistry Seminar ](/seminars/inorganic-chemistry-seminar)
 
 

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