#  Dan Weix (U Wisconsin-Madison) 

 



####  calendar\_today Date and Time 

 **September 25, 2023** 

 04:15PM - 05:15PM EDT 

####  pin\_drop Location 

 **Pfizer Lecture Hall**  



 

 



 

 Title: New Chemical Space from Cross-Electrophile Coupling

 The primary challenge for synthetic chemists is supporting the efficient exploration of chemical space to find the best molecules for understanding or solving problems. In the past decade, cross-electrophile coupling, the union of two different electrophiles through transition-metal catalysis under reducing conditions, has become an increasingly used tool in these efforts. By focusing method development on the largest pools of pre-functionalized molecules, the millions of available carbon electrophiles, chemical space can be more efficiently accessed than through reactions limited to the thousands of carbon nucleophiles. Development of these reactions requires the development of strategies to utilize the most abundant electrophile pools and to ensure the reactions favor the cross-coupled product over potential homodimeric products. Guided by mechanistic understanding, we have developed general strategies tailored to C(sp2)-C(sp2), C(sp2)-C(sp3), and C(sp3)-C(sp3) bond formation based upon differential modes of activation (two-electron vs single-electron), multimetallic catalysis, and utilizing the general idea of persistent vs transient intermediates. This talk will briefly introduce the mechanistic underpinnings of selectivity in cross-electrophile coupling reactions and then discuss recent developments and new reactions. In particular, this talk will explore the use of new types of electrophiles derived from ketones, amines, carboxylic acids, and alcohols, and less reactive electrophiles, such as organic chlorides and sulfonate esters. Finally, applications to industrial challenges both large and small will be presented.



 



 

 



 

 See also:- [ Woodward CCB Departmental Colloquium ](/seminars/woodward-ccb-departmental-colloquium)
 
 

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