#  Jim Wells (UCSF) 

 



####  calendar\_today Date and Time 

 **April 4, 2024** 

 04:15PM - 05:15PM EDT 

####  pin\_drop Location 

 **Pfizer Lecture Hall**  



 

 



 

 Title: Attacking the Cancer Surfaceome

 The cell surface proteome, the surfaceome, is a major hub for cellular communication and a primary source of drug targets, especially for biologics. Identifying how the surfaceome changes in cancer is a central challenge for identifying and targeting new disease associated proteins. We have used chemical methods and engineered proteins to facilitate identification of membrane proteins, both native and post-translationally modified versions, that change with oncogene transformation and or hypoxia a characteristic of the tumor micro-environment. We then target proteins either upregulated, proteolyzed or both with recombinant antibodies derived by phage display to be used as validation tools and potential therapeutic leads.



 



 

 



 

 See also:- [ Woodward CCB Departmental Colloquium ](/seminars/woodward-ccb-departmental-colloquium)
 
 

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