#  Jonathon Long (Stanford) 

 



####  calendar\_today Date and Time 

 **April 13, 2023** 

 04:15PM - 05:15PM EDT 

####  pin\_drop Location 

 **Pfizer Lecture Hall**  



 

 



 

 Title: Chemical control of mammalian physiology

 Abstract: Chemical signaling is a fundamental mechanism for cell-cell communication in mammalian physiology. Here, I will discuss our recent work on chemical signals derived by enzymatic conjugation of amino acids and diverse organic acids. This biotransformation produces a large class of signaling metabolites that can be broadly classified as N-acyl amino acids. Our pharmacological gain-of-function studies, as well as genetic loss-of-function studies in mice, establish roles for N-acyl amino acids as metabolic messengers that regulate systemic energy homeostasis. Lastly, I will discuss our ongoing work on using humans as a model system for understanding the biochemistry, genetics, and physiology of this metabolite family.



 



 

 



 

 

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