#  Wenjing Wang (U Michigan LSI) 

 



####  calendar\_today Date and Time 

 **April 6, 2023** 

 04:15PM - 05:15PM EDT 

####  pin\_drop Location 

 **Pfizer Lecture Hall**  



 

 



 

 Title: Optogenetic and chemogenetic sensors and tools for studying brain signaling

 **Abstract:** G-protein coupled receptors (GPCRs), such as dopamine and opioid receptors, play critical roles in neuromodulation. It remains a major challenge to record or manipulate GPCR signaling events both with high spatial resolution and across a large brain volume. Fast Scan Cyclic Voltammetry and microdialysis allow the study of neuromodulator release events in the brain. However, they do not provide a cellular-resolution map of neuromodulators. GPCR-based genetically-encoded real-time sensors enable the investigation of neuromodulators with high spatiotemporal resolution. However, they are limited to the recording of a small brain region and do not allow further study of the neuronal population of interest. My research group focuses on designing integration sensors that can integrate the neuromodulator signal into a permanent mark in the cells for further investigation. We have designed an opioid sensor with the potential for whole-brain mapping. We are also extending this design to detect other neuromodulators across the brain. Additionally, we are designing genetically-encoded chemical-activated opioid peptides to enable cell type-selective manipulation of opioid receptors to study their causal-effect on pain modulation and addition.



 



 

 



 

 See also:- [ Woodward CCB Departmental Colloquium ](/seminars/woodward-ccb-departmental-colloquium)
 
 

 Share on:- [     Facebook ](#)
- [     Twitter ](#)
- [     Linkedin ](#)
 


 Save: [ Add to calendar calendar\_today ](https://www.chemistry.harvard.edu/node/1443181/event-feed.ics)  Copy link link