#  Special Seminar - Dr. Serge Ruccolo, Merck 

 



####  calendar\_today Date and Time 

 **September 19, 2022** 

 04:30PM - 05:30PM EDT 

####  pin\_drop Location 

 **Pfizer Lecture Hall**  



 

 



 

 **Talk Title: "**Electrochemical Recycling of Adenosine Triphosphate in Biocatalytic Cascades." **ABSTRACT:** Adenosine triphosphate (ATP) provides the driving force necessary for critical biological functions in all living organisms. In synthetic biocatalytic reactions, this cofactor is recycled *in situ* using high-energy stoichiometric reagents, an approach that generates waste and poses challenges with enzyme stability. On the other hand, an electrochemical recycling system would use electrons as a cheap and green source of energy. We developed a method that uses electricity to turn over enzymes for ATP generation in a simplified cellular respiration mimic. The method is simple, robust, and scalable, as well as broadly applicable to complex enzymatic processes including a four-enzyme biocatalytic cascade in the synthesis of the antiviral molnupiravir.



 

 

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 Attachments- [  picture\_as\_pdf  serge\_ruccolo.pdf ](/sites/g/files/omnuum7776/files/chemistry/files/serge_ruccolo.pdf)
 
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 See also:- [ Special Seminars ](/seminar-series/special-seminars)
 
 

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