#  Insulin-Degrading Enzyme Inhibitor is Validated 

 





May 22, 2014

 

 

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Researchers in the Liu and Saghatelian groups have identified and tested a new compound that regulates the degradation of insulin in animals. With the use of DNA-templated synthesis, a library of small molecules was generated, one of which demonstrated good inhibitory behavior in vivo. [The research](http://news.harvard.edu/gazette/story/2014/05/strategy-for-diabetes-treatment/?utm_source=SilverpopMailing&utm_medium=email&utm_campaign=05.22.daily%201), published in the May 21st issue of [Nature](http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13297.html), also revealed that insulin-degrading enzyme has more complex functions than its name implies: namely, inhibiting the glucose-regulating peptide hormones glycagon and amylin, in addition to insulin.



 

 

 



 

 

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