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X-WR-CALNAME;VALUE=TEXT:Ian Seiple
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SUMMARY:Ian Seiple
DESCRIPTION:<span style="caret-color:rgb(0,0,0);color:rgb(0,0,0);-webkit-standard;medium;font-style:normal;font-variant-caps:normal;font-weight:normal;letter-spacing:normal;orphans:auto;text-align:start;text-indent:0px;text-transform:none;white-space:normal;widows:auto;word-spacing:0px;-webkit-text-size-adjust:auto;-webkit-text-stroke-width:0px;text-decoration:none;display:inline!important;float:none;">Professor Ian Seiple, University of California, San Francisco, "Fully synthetic routes to unlock natural product potential", </span><span style="color:rgb(30,30,30);Montserrat,sans-serif;15px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:300;letter-spacing:normal;orphans:2;text-align:start;text-indent:0px;text-transform:none;white-space:normal;widows:2;word-spacing:0px;-webkit-text-stroke-width:0px;background-color:rgb(255,255,255);text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;display:inline!important;float:none;">Woodward CCB Departmental Colloquium. </span><!--break--><p>	 </p><p style="-webkit-text-stroke-width:0px;text-align:justify">	Abstract:<span style="caret-color:#000000"><span style="color:#000000"><span><span style="font-style:normal"><span style="font-variant-caps:normal"><span style="font-weight:normal"><span style="letter-spacing:normal"><span style="orphans:auto"><span style="text-transform:none"><span style="white-space:normal"><span style="widows:auto"><span style="word-spacing:0px"><span style="-webkit-text-size-adjust:auto"><span style="text-decoration:none"><span><span style="sans-serif"> Many classes of natural products have tremendous potential as therapeutics or as biological tools but have structural liabilities that limit their utility. Our lab uses modular chemical synthesis to enable systematic modification of promising natural products to overcome such liabilities. We use structural data (cryo-EM or X-ray) to inform structural changes to improve potency, increase chemical stability, and reduce pharmacological liabilities. In this talk I will discuss several examples of this approach applied to molecules with anticancer, antibiotic, and antiviral properties.</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p><p>	<!--break--></p><p>	Helen L. Schwickrath is inviting you to a scheduled Zoom meeting.</p><p>	Topic: Hybrid CCB Seminars<br>Time: Mar 24, 2022 04:00 PM Eastern Time (US and Canada)<br>        Mar 24, 2022 04:00 PM<br>        Mar 31, 2022 04:00 PM<br>        Apr 7, 2022 04:00 PM<br>        Apr 14, 2022 04:00 PM<br>        Apr 21, 2022 04:00 PM<br>        Apr 28, 2022 04:00 PM<br>Please download and import the following iCalendar (.ics) files to your calendar system.<br>Daily: https://harvard.zoom.us/meeting/tJYudu6pqjMpG9HwWy_FRg20l_-6HH3vqs1x/ics?icsToken=98tyKuCqrTotG9CdsxiCRowQA4j4KOvwiFxejfp1iyj8PAZhZVGmOt0PZJpXQ87B</p><p>	Join Zoom meeting<br>https://harvard.zoom.us/j/92317148315?pwd=K0JnS2N6ZjJwY0JsTFFDaFJ5bmpudz09</p><p>	Password: 944632</p><p>	Join by telephone (use any number to dial in)<br>        +1 312 626 6799<br>        +1 929 436 2866<br>        +1 301 715 8592<br>        +1 346 248 7799<br>        +1 669 900 6833<br>        +1 253 215 8782</p><p>	International numbers available: https://harvard.zoom.us/u/aVm9pUvYd</p><p>	One tap mobile: +13126266799,,92317148315# US (Chicago)<br>    <br>Join by SIP conference room system<br>Meeting ID: 923 1714 8315<br>92317148315.944632@zoomcrc.com<br> </p>
LOCATION:Pfizer Lecture Hall
STATUS:CONFIRMED
DTSTART:20220414T201500Z
DTEND:20220414T211500Z
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