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X-WR-CALNAME;VALUE=TEXT:Special Seminar - Dr. Serge Ruccolo, Merck
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SUMMARY:Special Seminar - Dr. Serge Ruccolo, Merck
DESCRIPTION:<p>	<strong>Talk Title: "</strong>Electrochemical Recycling of Adenosine Triphosphate in Biocatalytic Cascades." <!--break--><strong>ABSTRACT: </strong>Adenosine triphosphate (ATP) provides the driving force necessary for critical biological functions in all living organisms. In synthetic biocatalytic reactions, this cofactor is recycled <em>in situ</em> using high-energy stoichiometric reagents, an approach that generates waste and poses challenges with enzyme stability. On the other hand, an electrochemical recycling system would use electrons as a cheap and green source of energy. We developed a method that uses electricity to turn over enzymes for ATP generation in a simplified cellular respiration mimic. The method is simple, robust, and scalable, as well as broadly applicable to complex enzymatic processes including a four-enzyme biocatalytic cascade in the synthesis of the antiviral molnupiravir.</p>
LOCATION:Pfizer Lecture Hall
STATUS:CONFIRMED
DTSTART:20220919T203000Z
DTEND:20220919T213000Z
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