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X-WR-CALNAME;VALUE=TEXT:Lu Wei (California Institute of Technology)
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SUMMARY:Lu Wei (California Institute of Technology)
DESCRIPTION:<p style="margin:0in">	<span><span><span><span>Title: Functional Bond-Selective Microscopy for Subcellular Bioanalysis</span></span></span></span></p><p style="margin:0in">	<!--break--></p><p style="margin:0in">	<span><span><span><span>Advances in optical spectroscopy and microscopy have revolutionized our understanding of</span></span> <span><span>biological functions at the sub-cellular levels. In this seminar, I will present our recent efforts in developing and applying next-generation bond-selective spectro-microscopy for retrieving functional chemical information in live cells and neurons. I will first discuss the coupling of the stimulated Raman scattering (SRS) imaging, a nonlinear Raman imaging modality, with newly developed biorthogonal chemical strategies for </span></span><span><span>quantitative subcellular analysis of protein aggregates</span></span><sup> </sup><span><span>in neurodegenerative diseases and for intracellular local environmental sensing through alkyne-<span><span><span><span><span><span><span> hydrogen–deuterium exchange</span></span></span></span></span></span></span> (Alkyne-HDX). I will then present a new mid-infrared near-infrared double-resonance imaging technique, BonFIRE, for bond-selective fluorescence imaging with single-molecule sensitivity. This microscopy platform will allow new capabilities for wide-field super-multiplex imaging and vibrational lifetime imaging for sensing heterogeneous cellular interactions and environment. </span></span></span></span></p>
LOCATION:Pfizer Lecture Hall
STATUS:CONFIRMED
DTSTART:20241028T201500Z
DTEND:20241028T211500Z
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