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X-WR-CALNAME;VALUE=TEXT:Professor Eszter Boros (University of Wisconsin-Minnesota)
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SUMMARY:Professor Eszter Boros (University of Wisconsin-Minnesota)
DESCRIPTION:<p>Talk title: <em><strong>Catch and Release: Harnessing the Chemistry of Radioactive Metal Ions to Develop Next Generation Metal-based Medicines</strong></em></p><p>Abstract: Coordination chemistry enables us to transform short-lived, radiometal aqua-ions into tools for non-invasive, diagnostic imaging and disease-targeted radiotherapy for cancers. I will discuss our recent efforts in designing next-generation agents by employing rate-tunable, metal-mediated amide bond cleavage (rTMAC) of trivalent, transition-metal ions and metalloids. Specifically, I will describe how mechanistic understanding allows us to harness reactivity for in situ radiometal separation, pharmacokinetic tuning and timed drug-release. Finally, I will demonstrate how we can adapt rTMAC to rare earth metal ions by rational ligand design.</p>
LOCATION:MIT
STATUS:CONFIRMED
DTSTART:20260304T210000Z
DTEND:20260304T223000Z
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